LRRK2 and Dystonia: PINK1 pathogenic variants were also associated with abnormal central somatosensory processing (51); (4) The LRRK2 pathogenic variants are associated with pain, with painful dystonia reported in G2019S carriers (57, 58, 64) and G2019S and R1441C carriers reporting unspecified joint pain as their onset symptom (21, 61, 69).