This review was conducted to assess the presence of pain in patients with monogenic PD-related pathogenic variants, encompassing genes such as SNCA, PRKN, PINK1, LRRK2, ATP13A2, PARK7, VPS35, GBA1, DNAJC6, FBXO7, and SYNJ1. The central findings of this review offer valuable insights into the connection between specific gene pathogenic variants and the occurrence of pain in individuals with PD. The gene discussed is VPS35; the disease is Parkinson disease.