Monoamine neurotransmitters are the most important pathogenetic mechanism in PSD, and inflammatory cytokines and microglia can cause a decrease in 5-HT in the brain; altered ratios of monocytes, neutrophils, and lymphocytes can be used as a predictive biomarker for PSD, and there is a correlation between higher proinflammatory factors, NLRP3, TGF-β, Hs-CRP, Hcy with PSD, and the PSD interconnection between neurotrophic factor, neuroendocrine abnormalities, and The interconnections between stroke lesion sites and neurotransmitters involve multiple systems in the body thereby inducing PSD. Here, NLRP3 is linked to Stroke.