TGFB1 and Stroke: Monoamine neurotransmitters are the most important pathogenetic mechanism in PSD, and inflammatory cytokines and microglia can cause a decrease in 5-HT in the brain; altered ratios of monocytes, neutrophils, and lymphocytes can be used as a predictive biomarker for PSD, and there is a correlation between higher proinflammatory factors, NLRP3, TGF-β, Hs-CRP, Hcy with PSD, and the PSD interconnection between neurotrophic factor, neuroendocrine abnormalities, and The interconnections between stroke lesion sites and neurotransmitters involve multiple systems in the body thereby inducing PSD.