In another study, a total of 151 patients with acute ischemic stroke were screened at baseline and completed a 1-month follow-up, serum IL-10 levels were measured within 24 h of admission, and depressive symptoms were assessed using the 17-item Hamilton Depression Scale (HAMD-17), with PSD defined as a HAMD score of ≥7. This evidence concerns the gene IL10 and major depressive disorder.