This result was consistent with the treatment of S. suberectus –H and S. suberectus -L on the tumor tissues of xenografted mice which downregulated the expression of EGFR, Ras, Raf, MEK, p-MEK, ERK1/2 and p-ERK1/2 (Fig. 4A). The gene discussed is MAPK3; the disease is neoplasm.