When primary monocytes from healthy donors were in co-culture with invariable tumor targets (Raji spheroids) we recognized that the efficacy of different RTX isotypes to induce ADP was in the order IgG3>IgG1>IgG4, IgA1, IgA2>IgG2, regardless of sex or age of donor. This evidence concerns the gene IGHG3 and neoplasm.