Diabetes mellitus is a metabolic disease associated with the abnormal or faulty digestion of carbohydrates (Giacco et al., 2016), fat (Hetz, 2012), and protein (Gomez-Serrano et al., 2017) metabolism, leading to either disrupted glucose homeostasis or impaired insulin secretion (Sudha, 2019). The gene discussed is INS; the disease is metabolic disease.