CAPN3 and autosomal recessive limb-girdle muscular dystrophy type 2A: Limb-girdle muscular dystrophy type 2A (LGMD2A), a subtype with higher prevalence among LGMDs, does not arise from a defect of the structural cellular composition, but rather from a defect of a skeletal muscle-specific protease, the Calpain 3 (CAPN3) [2–4].