Furthermore, animal models have demonstrated that IGFBP-4 can increase VEGF-induced angiogenesis [89] and that the m6A binding protein METTL3 can target VEGFA via IGFBP-2, encouraging the creation of colorectal cancer vasculogenic mimicry via the PI3K/AKT/mTOR and ERK1/2 signaling pathways [90]. Here, VEGFA is linked to colorectal cancer.