Samir et al. [84] reported that treating type 2 diabetes mellitus (T2DM) with L-carnitine resulted in improved immunohistochemical intensity of TRIM63. We also observed that the immunohistochemical staining intensity of markers that exacerbate skeletal muscle atrophy in T1DM, such as FBXO32, TRIM63, and FoxO3a, decreased in response to treatments. This evidence concerns the gene FOXO3 and Skeletal muscle atrophy.