Age, gender, BMI, smoking, duration of diabetes, hypertension, low-density lipoprotein cholesterol (LDL-C), hypersensitive C-reactive protein (hs-CRP), anemia, diabetic neuropathy, DN, ASCVD, low education, OAD, insulin, and ACEI/ARB were included as covariates in the multivariable analysis. The gene discussed is INS; the disease is Hypertension.