IFNγ receptor genes IFNGR1, IFNGR2 and the downstream effector IRF1 have been reported to be expressed on a PNET cell line QGP-1, and IFNγ treatment could inhibit tumor growth and induce apoptosis in vitro, indicating a direct anti-PNET effect of IFNγ (22). Here, IRF1 is linked to neoplasm.