POSTN exerts different roles in tissue development and disease progression, including brain injury, ocular diseases, chronic rhinosinusitis, allergic rhinitis, dental diseases, atopic dermatitis, scleroderma, eosinophilic esophagitis, asthma, cardiac diseases, lung diseases, liver diseases, chronic kidney diseases, inflammatory bowel disease, and osteoarthrosis (29) (Figure 1). This evidence concerns the gene POSTN and osteoarthritis.