The endothelium actively engages in the establishment of MODS, as evidenced by clinical studies reporting increased circulating levels of EC-derived proteins including soluble E-selectin, VCAM-1, VE-cadherin, PECAM-1, VEGFR1, ANGPT-2, IL-8, VWF, TM, tPA, PAI-1, and glycocalyx constituents in sepsis patients (8–11, 117–123). The gene discussed is VWF; the disease is Sepsis.