For example, they showed that treatment with activated protein C (Xigris) which, despite its dual action as an anticoagulant and involvement in protecting the vascular barrier, was discontinued as a therapy for sepsis due to an increased bleeding risk (203, 215), would improve outcome in patients with sepsis-induced disseminated intravascular coagulopathy whereas for other phenotypes it was indicated to be harmful (214). Here, PROC is linked to Sepsis.