THBD and Sepsis: Furthermore, patients with sepsis have systemically elevated levels of vascular cell adhesion molecule 1 (VCAM-1), vascular endothelial cadherin (VE-cadherin), EC-derived coagulation factors such as von Willebrand factor (VWF) and soluble thrombomodulin, as well as angiopoietin-1 and -2, thus strongly implying engagement of the endothelium in the body’s response in sepsis (8–12).