In patients with ANCA-associated vasculitis (AAV), the serum level of IL-18 was elevated (132) and the tissue protein content of NOD2, NLRP3, and NLRC5 was higher than that in healthy controls, demonstrating the role of the inflammasome in these disorders. This evidence concerns the gene NLRC5 and anti-neutrophil cytoplasmic antibody-associated vasculitis.