Nevertheless, CaV2.2 knockout mice are associated with altered pain sensation and other phenotypes.12 These channels are particularly important for neurotransmission at primary afferents, including nociceptor terminals,13,14 and also in the sympathetic nervous system.15 A human variant in CACNA1B was linked to myoclonus–dystonia syndrome, although this was then disputed.10,11 A recent study identified novel risk loci in a genome-wide association (GWAS) analysis of Parkinson’s disease and schizophrenia, including a single-nucleotide polymorphism (SNP), Rs2278973, in CACNA1B. Here, CACNA1B is linked to Parkinson disease.