We found three significant GO terms, which are ‘neuromuscular process controlling balance’, ‘mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)’, ‘carbonyl reductase (NADPH) activity’ among the five significant proteins (ADAM22, ATP5C1, DHRS2, RAC3, and SHANK1) associated with an improved prognosis of GBM (Fig 4A and 4B). The gene discussed is ADAM22; the disease is glioblastoma.