In summary, the overexpression of C1RL, CCL2, CHI3L1, CLEC5A, EMP3, FBXO17, MSN, SERPING1, STEAP3, SWAP70, TIMP1, and TMEM22 genes appears to influence the prognosis of patients with GBM by causing an immune-suppressive GBM microenvironment. The gene discussed is CHI3L1; the disease is glioblastoma.