According to our findings, 10 genes including ADAM22, AEBP1, CHL1, EFEMP2, PDPN, PGCP, RAC3, SHANK1, SWAP70, and TRIP6 appeared to influence the prognosis of GBM through mechanisms involving cell adhesion or structural and extracellular matrix. The gene discussed is SHANK1; the disease is glioblastoma.