Based on our investigation, among the 33 significant genes, there were 12 significant genes that appeared to be related to the GBM immune microenvironment and may affect the prognosis of GBM: C1RL, CCL2, CHI3L1, CLEC5A, EMP3, FBXO17, MSN, SERPING1, STEAP3, SWAP70, TIMP1, and TMEM22. This evidence concerns the gene EMP3 and glioblastoma.