TNF and cancer: In parallel, KEGG pathway analysis on these targets showed that these proteins mainly involved in 245 pathways, especially Pathways in cancer, Metabolic pathways, PI3K-Akt signaling pathway, Prostate cancer, HIF-1 signaling pathway, Neuroactive ligand-receptor interaction, MicroRNAs in cancer, TNF signaling pathway, Hedgehog signaling pathway and Osteoclast differentiation (S7 Table).