TG and hepatitis B virus infection: Further KEGG pathway enrichment analysis on these hub genes showed that the genes involved in the interaction network were involved in the Thyroid hormone signaling pathway, Hepatitis B, Basal cell carcinoma, TGF-beta signaling pathway, Th17 cell differentiation, Kaposi sarcoma-associated herpesvirus infection, Human T-cell leukemia virus 1 infection and, again, the Hedgehog signaling pathway (Fig 1D).