As expected, m276-SL-PBD selectively killed CD276+ HEK293 (293), HCT116 colon cancer, and UACC melanoma cells (Figure S1A) with an IC50 in the low picomolar range, indistinguishable from our previous m276-glyco-PBD ADC (Figures 1C-1E). This evidence concerns the gene CD276 and malignant colon neoplasm.