and Graham et al (334) demonstrated that AgRP is a selective MC3R and MC4R competitive antagonist inhibiting the effects of αMSH, with transgenic mice overexpressing the human AGRP and mouse Agrp genes gaining significant amounts of weight and developing glucose intolerance and insulin insensitivity compared with their littermates, but with no change in pigmentation (ie, no effects on MC1R). The gene discussed is AGRP; the disease is Glucose intolerance.