POMC and Adrenal insufficiency: Similarly POMC deficiency can result in a clinical phenotype not just easily attributable to deficits in the secretion of all its constituent peptides (HyOb [αMSH], central hypoadrenalism [ACTH], red hair, and pale skin [αMSH]), but also consisting of other hypothalamo-pituitary hormone deficiencies due to interactions between the POMC system and these axes (428, 443).