GCG and Anorexia: Cell-specific Glp1r mouse knockdown experiments in PVN and POMC neurons, however, suggest that GLP-1 appears to work independently of these networks, as these mice did not exhibit changes in food intake or weight (although PVN Glp1r knockdown mice showed a reduction in energy expenditure), and GLP-1 agonist administration still led to anorexia and improved glucose tolerance (153).