GH1 and diabetes mellitus: More than 10 years later, similar studies of medical treatment for hyperinsulinemia using octreotide (a SS analogue) in children with HyOb resulted in a minimal reduction in BMI in some patients (mean BMI reduction of −0.2 kg/m2 in an RCT setting), but with the side effects of diarrhea, abdominal discomfort, cholelithiasis, diabetes mellitus, and impairment of the GH and TSH hypothalamo-pituitary axes (322, 512, 515).