NFKB1 and Intervertebral disk degeneration: In intervertebral disc degeneration, activation of the TNF-α/NF-κB signaling pathway leads to the secretion of inflammatory factors from nucleus pulposus cells, promoting the generation of an inflammatory microenvironment in nucleus pulposus tissue and causing a homeostatic imbalance in the nucleus pulposus tissue internal environment [5, 47].