CNR1 and melanoma: In such a situation, the inhibition of AEA hydrolysis along with a consecutive increase in AEA concentrations and/or prolonged action of AEA on CB1 and CB2 receptors in response to AM1172-mediated effect (i.e., inhibition of cellular uptake of AEA) produced not only the antiproliferative effects in various human melanoma cell lines but also on normal human cells, suggesting that AM1172 cannot be used alone as a potential chemotherapeutic drug.