As PKM2 is a key enzyme of aerobic glycolysis in tumor metabolism and a key down-target of PI3K/Akt and MAPK signaling pathways [15, 25, 26], whereas β-arrestin2, a pivotal adapter in PI3K/Akt and MAPK signal transduction, is also involved in the metabolic and cellular process that responses to chemical stimulus [14, 22, 27, 28]. This evidence concerns the gene PKM and neoplasm.