Although HOX10 has been reported as an activator of canonical NF-κB signaling in pancreatic cancer cells (60), and although the antisense to HOXA11 (HOXA11-AS) was linked to protection of EC barrier function following injury (61), insight into the potential role of these genes in the EC TNF response is currently lacking. The gene discussed is NFKB1; the disease is familial pancreatic carcinoma.