Genes that were upregulated following TNF treatment in the turquoise module (Fig. 3B) included those encoding for a panel of IFN-induced cytokine ligands for the APC receptor CXCR3: CXCL9, CXCL10, and CXCL11 (Fig. 3Biii), the expression of which is linked with viral infection, progression, and replication control (54–56). This evidence concerns the gene CXCL10 and viral infectious disease.