As murine STAT1 is resistant while human STAT1 is sensitive to ZIKV infection-induced cleavage, we compared the amino acid sequence of human STAT1 and murine STAT1 and found that the amino acid at 694 and 695 positions of human STAT1 is DG (aspartic acid and glycine), while the amino acid at the corresponding position of murine STAT1 is DD (aspartic acid and aspartic acid). Here, STAT1 is linked to Zika virus infectious disease.