In recent research, VRAC-mediated AVD has been shown to be related to the anti-apoptotic effect of cancer cells towards the anticancer drug cisplatin, a DNA-damaging agent, as it plays a significant role in the intrinsic apoptotic pathway, including the expression of BAX/Bcl-2 and activation of caspase-9/3/7 [37]. The gene discussed is CASP9; the disease is cancer.