The incidences of RP‐ILD, arthritis, myositis, triad, mechanic's hands, and shawl sign were more frequent in the anti‐Ro52 antibody‐positive group than the anti‐Ro52 antibody‐negative patients with ASS (p = .0.034, = 0.009, <.001, <.001, = 0.010, and = 0.048, respectively). Here, TRIM21 is linked to interstitial lung disease.