Combined with the previous studies that miR‐122‐5p affects IR in hepatocytes by targeting IGF‐1R and miR‐182‐5p inhibits IGF‐1R expression in hepatocellular carcinoma,15, 23 we conjectured that miR‐182‐5p may regulate hepatic IR by binding to IGF‐1R, which was then confirmed by our experimental results. This evidence concerns the gene IGF1R and hepatocellular carcinoma.