Ultimately, a gene signature consisting of seven overlapping genes (ATP7A, FDX1, PDHA1, PDHB, MTF1, CDKN2A, and DLST) was identified as the optimal cuproptosis‐related signature for predicting MM diagnosis, with an AUC value of 0.887 in the training cohort. Here, DLST is linked to Miyoshi myopathy.