We studied 3 groups of subjects: 14 controls, 6 subjects with heterozygous LCAT deficiency (LCAT+/-), and 6 with LCAT deficiency (LCAT-/-).31 Two of the LCAT-/- subjects were unrelated to the subjects in the family study. The gene discussed is LCAT; the disease is hyperinsulinemic hypoglycemia, familial, 4.