We mainly simulated the docking of 3 active compounds (quercetin, naringenin, and kaempferol) of bitter almond-licorice with ACE2 (PDB ID: 1R42) (Figs. 8A-D), and the results showed that compared with hydroxychloroquine, these active ingredients combined with ACE2 generally ideal, indicating that these 3 active ingredients had the potential to treat COVID-19. The gene discussed is ACE2; the disease is COVID-19.