To provide the scientific basis for the treatment of COVID-19 with Chinese medicine, this study illustrated the mechanisms of how the bitter almond-licorice treat COVID-19 by the network pharmacology, and revealed that the 89 active ingredients of the bitter almond-licorice acted on COVID-19 through 102 targets which contained core targets, such as IL6, MAPK1, TNF, and IL1B, and that these active components are involved in numerous biological pathways and molecular interactions in the body, and act synergistically. The gene discussed is TNF; the disease is COVID-19.