Among these, the expression of CRHR1 was more sensitive than CRHR2 and the higher protein level was found in the amygdala in SPS, while the OXT signaling pathway demonstrated a therapeutic specificity to the amygdala, indicating that the amygdala OXT signaling pathway may amended SPS induced PTSD by regulating CRHR1 [64]. The gene discussed is OXT; the disease is post-traumatic stress disorder.