Recently, TNF-α and IL-6 silencing siRNA (siRNAT/I) and Prussian blue nanoparticles (PBNPs) encapsulated by macrophage membrane vesicles (MMVs) have been used to develop biomimetic nanoparticles M@P-siRNAsT/I which target RA joints (Fig. 12A) [185]. This evidence concerns the gene TNF and rheumatoid arthritis.