The TMB score was computed after dividing the total sum of somatic mutations by size of exomes, and the findings implied that the high-risk HNSCC patients showed a high number of somatic mutations in comparison to low-risk HNSCC patients, specifically for TP53. Loss of TP53 might influence the survival of tumors after radiation or chemotherapy and it could influence the patient’s prognosis [36]. Here, TP53 is linked to head and neck squamous cell carcinoma.