Our current study shows that high expression of A2B1 in HCC reduces m6A-containing PCK1 mRNA levels, however, knockout of A2B1 dramatically increases m6A methylated mRNA levels of PCK1, implying that A2B1 recognizes m6A sites of PCK1 and likely promotes the degradation of PCK1 mRNA. The gene discussed is PCK1; the disease is hepatocellular carcinoma.