PCK1 and hepatocellular carcinoma: However, gluconeogenesis related rate-limiting enzymes Fructose-Bisphosphatase 1 (FBP1), Glucose-6-Phosphatase Catalytic Subunit 1 (G6PC), PC (pyruvate carboxylase), phosphoenolpyruvate carboxykinase 1 (PCK1), and PCK2 were negatively correlated with the expression level of hnRNPA2B1 in HCC (Fig. 5C).