MMP1 and ductal breast carcinoma in situ: Importantly, both MMP ratios significantly predicted which DCIS patients will progress to invasive disease (AUC 3’MMPs/5’MMPs ratio = 0.67, AUC of MMP1/MMP8 = 0.77; Fig. 6e and f), but not, but not 3’MMPs and 5’MMPs signatures tested individually (Supplementary figures S11b).