CD8A and neoplasm: The MPEI/pCAR-IFN-γ injected into Neuro-2a tumor-bearing mice notably halted tumor growth with no clue of systemic toxicity, decreased the Treg cell and increased activated CD8+ T cells in the tumors. Additionally, CAR-M enhanced the function of CD8+ T cells, likely by CAR-dependent tumor cell phagocytosis [120].