The VEGF binds to its receptor (VEGF receptor 2) and starts the proliferation and maturation of the endothelial cells (EC), improving the chemotaxis of EDs and macrophages by helping the MMP-2, MMP-7, and MMP-9 that breaking down the extracellular matrix and improve the ECs migration and create new vessel buds and progress the tumor invasion [49, 50]. The gene discussed is VEGFA; the disease is neoplasm.