In addition, knocking out some agents that precipitate in M2 phenotype polarization and promote tumor survival have been known to be targeted in macrophage but not used in CAR M manner; for example these factors like kindlin2, osteopontin, lysosome-associated membrane protein type 2A (LAMP2a), IL-8, and tumor-secreted protein S (Pros1) [253]. This evidence concerns the gene CXCL8 and neoplasm.