As for the functional aspect, GPC1 could represent an interesting TAA to target with immunotherapeutics, also because it is associated with several growth factors such as fibroblast growth factor 2 (FGF2), vascular endothelial growth factor (VEGF), heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor-β (TGF-β), which are involved in cancer cell proliferation, angiogenesis and metastasis [24]. The gene discussed is HBEGF; the disease is cancer.