In this study, differential gene analysis of 32 children with CKD-PEW concluded that the related genes included: CRP, IL6, TNF, IL1B, CXCL8, IL12B, IL12A, IL18, IL1A, IL4, IL10, TGFB2, TGFB1, TGFB3, ADIPOQ, NAMPT, RETN, RETNLB, LEP, CD163, ICAM1, VCAM1, SELE, NFKB1, NF-ΚB and so on, a total of 25 genes, including CRP, IL6, TNF, IL1B, IL12B, IL12A, IL18, IL1A, IL4, IL10, NFKB1, NF-ΚB and many other genes have been reported to be closely related to chronic inflammatory response, which is consistent with the our conclusion [19]. The gene discussed is IL18; the disease is chronic kidney disease.