In eWAT from DKO mice, we detected protein upregulation of a plethora of local protective factors (such as CES1D, MYDGF, PLIN1, CAVIN, PPM1A, CREG1, FGFR1, SOD3, and MFN2) against metabolic dysregulation, inflammation, reprogramming of the diabetic gene signature in WAT and other tissues including non-alcoholic fatty liver disease, impairment of brown adipose tissue thermogenesis, and in atherosclerosis [55–66]. Here, CREG1 is linked to atherosclerosis.