In line, proteomic analyses of aortas from DKO mice revealed upregulation of anti-inflammatory and atheroprotective markers and vasorelaxation mediators (ITIH4, LRP8/APOER2, MBL2, DBN1, PARK7/DJ-1) [83–87], whereas proteins related to the progression of atherosclerosis (DIAPH1) [88], foam cell formation and macrophage ferroptosis (IDH1) [89], and endothelial dysfunction and reactive oxygen species (ROS) production (XDH) [90] were downregulated. This evidence concerns the gene ITIH4 and atherosclerosis.