The non-NRG signature exhibited significant correlations (P < 0.05) with several clinical features, including gender, tumor stage, T classification, lymph node metastasis, and distal metastasis, as well as mutational features such as EGFR mutation, KRAS mutation, and TP53 mutation (Figure S3). Here, EGFR is linked to metastatic malignant neoplasm in the lymph nodes.