The non-NRG signature exhibited significant correlations (P < 0.05) with several clinical features, including gender, tumor stage, T classification, lymph node metastasis, and distal metastasis, as well as mutational features such as EGFR mutation, KRAS mutation, and TP53 mutation (Figure S3). The gene discussed is KRAS; the disease is metastatic malignant neoplasm in the lymph nodes.