The results indicated significant correlations between the NRG signature and various factors: gender (P = 0.01), tumor stage (P = 0.012), T classification (P = 0.003), lymph node metastasis status (P < 0.001), KRAS mutation status (P = 0.02), and TP53 mutation status (P < 0.001). Here, KRAS is linked to neoplasm.