Interesting, metabolism-related genes, such as BRCA1, MAPK3, CYP7A1, and AKR1C3, serve as the core nodes of this network connecting other pathways, including phosphatase interacting and non-interacting auto/mitophagy pathways, TF dependent transcriptional regulation and immune response after CTD treatment in HCC. The gene discussed is AKR1C3; the disease is hepatocellular carcinoma.