However, we found several novel targets of CTD related to autophagy that had not been previously reported, such as GABARAP, GABARAPL1, ALB, RAB7B, ATG101, GLCN, MEFV, NOD, and MAPT. Moreover, we confirmed that the CTD-downregulated genes TOP2A, CENPF, ACSL4, SPARC, and COL4A5 were significantly increased in liver cancer patients, while upregulated genes PLK3, C9orf72, TRIM22, RNF152, FEZ1 and MEFV were dramatically decreased in liver cancer patients. The gene discussed is TOP2A; the disease is liver cancer.