KL and diabetes mellitus: Although interaction between diabetes and Klotho (≥ 870.7 pg/ml), sex and Klotho (≥ 870.7 pg/ml), as well as diabetes and Klotho (< 870.7 pg/ml) on accelerated aging was observed in the present study, due to chance given multiple testing and similar directionality of most of the associations, these results may not have significant clinical implications.