AFP and hepatocellular carcinoma: As shown in Fig. 5D, the area under the curve (AUC) differentiating HBV-HCC patients from healthy controls and CHB patients was 0.8242 (95%CI: 0.7101–0.9383) for AFP and 0.7877 (95%CI: 0.6848–0.8906) for SUV39H1, indicating that both SUV39H1 and AFP have high diagnostic potential.