The downregulation of argininosuccinate synthetase (ASS1), phosphoglycerate dehydrogenase (PHGDH), and glutamic-oxaloacetic transaminase 1 and 2 (GOT1 and GOT2) in both chRCC and RO tumors compared with NAT confirms this result [24]. This evidence concerns the gene PHGDH and chromophobe renal cell carcinoma.