APLP1 and neurodegenerative disease: Several genes involved in amyloid production were also found to be dysregulated by RH, including Aplp [18], Rtn1 [15] and Itm2b [20], all of which have been associated with amyloid beta (Aβ) protein formation, and Resp18 [14], Psap [16], Ubb [17] and Cst3 [19], all of which are associated with neurodegenerative diseases.