PMP22 and Charcot-Marie-Tooth disease type 1A: Impaired proliferation and apoptotic cell death of differentiating Schwann cells is a potential characteristic of CMT1A pathology34, which is supported by previous studies including retrovirus vector-mediated PMP22 gene transfer in cultured Schwann cells50, Schwann cells isolated from nerve biopsies of CMT1A patients51, and PMP22 overexpression in Schwann cells and NIH-3T3 cells52,53.