From the diagnostic capacity analysis, in the GSE14520 cohort, APOL1 and APOL6 had diagnostic significance for HCC (APOL1: area under curve [AUC] 0.824, P < 0.0001; APOL6: AUC 0.775, P < 0.0001, Fig. 2A,E). The gene discussed is APOL6; the disease is hepatocellular carcinoma.