In previous studies, we analyzed the protein expression of relevant genes from the two major PCa pathways, mainly PTEN, SPOP, SLC45A3, ETV1 and ERG, as well as the “triple hit” combination (ERG overexpression, PTEN plus SLC45A3 loss), and we reported relevant associations between changes in these molecules and the clinicopathological features of the tumors [21–23]. Here, SPOP is linked to posterior cortical atrophy.