Briefly, IHC and quantitative analysis of 280 treatment-naïve PCa patients showed an intermediate or strong and constant GR staining in the stromal compartment in both benign and malignant tissue sections, in contrast to a significantly reduced epithelial GR staining in primary PCa compared to benign prostate glands (Fig. 1B, C). Here, NR3C1 is linked to posterior cortical atrophy.