TP53 and diffuse large B-cell lymphoma: RT usually has the histological characteristics of a diffuse large B-cell lymphoma (DLBCL), but with specific molecular lesions, such as specific stereotyped BCR immunoglobulins (subset #8), NOTCH1 mutations, TP53 inactivation, MYC translocations or amplifications, CDKN2A deletions, and complex karyotypes [7, 8].