RT usually has the histological characteristics of a diffuse large B-cell lymphoma (DLBCL), but with specific molecular lesions, such as specific stereotyped BCR immunoglobulins (subset #8), NOTCH1 mutations, TP53 inactivation, MYC translocations or amplifications, CDKN2A deletions, and complex karyotypes [7, 8]. The gene discussed is NOTCH1; the disease is diffuse large B-cell lymphoma.