To assess the impact of concomitant alterations of ASXL1 and splicing factors in accelerating the progression and aggressiveness of myeloid malignant, we performed mutual exclusivity analysis using 10 377 myeloid malignancies (https://www.cbioportal.org/) for ASXL1 and splicing factors mutations. Here, ASXL1 is linked to myeloid neoplasm.